Inhibitors of voltage-gated sodium channels

Details Inhibitors of voltage-gated sodium channels Inhibitors of voltage-gated sodium channels

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/4152 (2006.01) A61K 31/4178 (2006.01) A61K 31/4192 (2006.01) A61K 31/4196 (2006.01) A61K 31/506 (2006.01) A61P 25/04 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2620179

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides heterocyclic aryl sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

L~invention concerne des composés, des compositions et des méthodes utiles dans le traitement de maladies par inhibition du flux d'ions sodium à travers les canaux sodium sensibles au voltage. Plus particulièrement, l'invention permet d~obtenir des aryl sulfonamides hétérocycliques, des compositions et des méthodes utiles dans le traitement de troubles du système nerveux central ou périphérique, en particulier de douleurs et douleurs chroniques en bloquant des canaux sodium associés avec l~apparition ou la récurrence des conditions indiquées. Les composés, compositions et méthodes de la présente invention sont d'une particulière utilité pour traiter la douleur neuropathique ou inflammatoire par inhibition du flux d'ions à travers un canal sodium sensible au voltage.

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