C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/40 (2006.01) C12N 9/02 (2006.01) C12Q 1/26 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2238014
Antigen binding polypeptides that specifically bind human cytochrome P450 3A3, 3A4, and 3A5 and that specifically inhibit the enzyme activity of human cytochrome P450 3A3, 3A4, and 3A5 are described. Antigen binding polypeptides that specifically bind to human cytochrome P450 3A3 and 3A4 are also described. Antigen binding polypeptides which specifically bind to human cytochrome P450 2E1 and which specifically inhibit the enzyme activity of human cytochrome P450 2E1 are described. Antigen binding polypeptides which specifically bind to human cytochrome P450 2E1 are also described. Methods of determining the contribution of human cytochrome P450s to the metabolism of compounds, using the antigen binding polypeptides of the invention, are also described.
L'invention décrit divers polypeptides de liaison d'antigènes et notamment des polypeptides liant spécifiquement les cytochromes humains P450 3A3, 3A4 et 3A5 et inhibant spécifiquement l'activité enzymatique des cytochromes précités; des polypeptides de liaison d'antigènes se liant spécifiquement aux cytochromes humains P450 3A3 et 3A4; des polypeptides de liaison d'antigènes se liant spécifiquement au cytochrome humain P450 2E1 et inhibant spécifiquement l'activité enzymatique de ce dernier; des polypeptides de liaison d'antigènes se liant spécifiquement au cytochrome humain P450 2E1; elle porte en outre sur des procédés de détermination de la contribution des cytochromes humains P450 au métabolisme de composés à l'aide des polypeptides de liaison d'antigènes.
Gelboin Harry V.
Gonzalez Frank J.
Fetherstonhaugh & Co.
United States Of America Represented By The Secretary Department Of Hea Lth And Human Ser
United States Of America Represented By The Secretary Of The Department Of Health And Hum
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