Inhibitory pas domain protein (ipas) and screening methods...

Details Inhibitory pas domain protein (ipas) and screening methods... Inhibitory pas domain protein (ipas) and screening methods...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 35/12 (2006.01) A61P 35/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2414995

The present invention relates a mammalian polypeptide designated Inhibitory PAS Domain Protein (IPAS) which polypeptide is useful for the inhibition of angiogenesis and/or tumor progression. The invention also relates to screening methods for compounds potentially useful as medicaments for the treatment of medical conditions related to angiogenesis or tumor progression.

L'invention concerne un polypeptide de mammifère appelé protéine inhibitrice du domaine PAS (IPAS) qui convient pour l'inhibition de l'angiogenèse et/ou de la progression d'une tumeur. L'invention concerne également des méthodes de criblage destinées à des composés potentiellement utiles comme médicaments pour le traitement de troubles médicaux relatifs à l'angiogenèse ou à la progression d'une tumeur.

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