Inhibitory tetrapeptide of entry into cycle of hemopoietic...

Details Inhibitory tetrapeptide of entry into cycle of hemopoietic... Inhibitory tetrapeptide of entry into cycle of hemopoietic...

C - Chemistry, Metallurgy

07

K

530/1, 530/5.1,

C07K 5/10 (2006.01) A61K 38/07 (2006.01) C07K 1/00 (2006.01) C07K 5/103 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1337731

The invention relates to a tetrapeptide corresponding to the general formula Ser-Asp-Lys-Pro-OH and its substitution derivatives by one or several groups, identical or different, currently used in the chemistry of peptides for biological use, as well as their pharmaceutically acceptable salts, in particular the tetrapeptide Ser-(N-Ac)-Asp-Lys-Pro-OH which can be extracted, for example, from fetal calf marrow or obtained by peptide synthesis. The peptide of the invention is particularly useful in the protection of bone marrow in the course of anti-cancer treatments by chemotherapy.

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