Initially plastically deformable bone implant compositions

Details Initially plastically deformable bone implant compositions Initially plastically deformable bone implant compositions

A - Human Necessities

61

L

A61L 24/00 (2006.01) A61L 27/42 (2006.01) A61L 27/50 (2006.01) A61L 27/54 (2006.01) A61L 27/58 (2006.01)

Patent

CA 2564164

Moldable bone implants for use in a bone defect or wound include a plurality of biocompatible granules and a biocompatible polymer that together form an implant mass. The polymer is softened with a plasticizer to make the implant mass moldable or flowable. The plasticizer can dissipate or be extracted to cause the implant mass to harden. The implant mass can be shaped in-situ or ex- situ. Implants formed in-situ are shaped by the bone defect or wound. The implant becomes hard through contact with body fluids, which extracts the plasticizer from the implant mass. Bone implants formed ex-situ, such as in a mold, are shaped by a mold, for example, and then hardened by placing the implant mass in contact with a hardening agent, such as water, which extracts the plasticizer from the implant mass. The shaped, hardened implant can be placed into a bone defect of corresponding size and shape.

L'invention concerne des implants osseux moulables, utilisables dans un défaut osseux ou une blessure, qui comprennent une pluralité de granules biocompatibles et un polymère biocompatible formant ensemble un implant massif. Le polymère est amolli avec un plastifiant pour rendre l'implant massif moulable ou fluide. Le plastifiant peut se dissiper ou être extrait, ce qui provoque le durcissement de l'implant massif. Le plastifiant peut être formé in situ or ex situ. Les implants formés in situ le sont par le défaut osseux ou la blessure. L'implant durcit au contact de liquides organiques qui extraient le plastifiant de l'implant massif. Les implants osseux formés ex situ, tels que dans un moule, sont réalisés à l'aide d'un moule, par exemple, puis durcis au contact d'un agent de durcissement, tel que l'eau, qui extraie le plastifiant de l'implant massif. L'implant durci ainsi formé peut être placé dans un défaut osseux de taille et de forme correspondantes.

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