Injectable composition

Details Injectable composition Injectable composition

A - Human Necessities

61

K

A61K 9/08 (2006.01) A61K 31/4439 (2006.01) A61K 47/18 (2006.01)

Patent

CA 2548074

An injectable composition comprising a combination of 2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole (lansoprazole), its optically active compound or a salt thereof, and a chelating agent, which is used at pH 9 to 12. The injectable composition is excellent in stability and solubility, and has such a high-quality that particulate insolubles are not formed when the composition is kept and supplied in a glass container and even in a plastic container and also when the composition is kept in these container for a long time.

L'invention concerne une composition injectable comprenant en combinaison du 2-[[[3-méthyl-4-(2,2,2-trifluoroéthoxy)-2-pyridinyl]méthyl]sulfinyl]-1H-benzimidazole (lansoprazole), son composé optiquement actif ou un sel de celui-ci et un agent chélateur, ladite composition s'utilisant à un pH compris entre 9 et 12. Cette composition injectable présente d'excellentes caractéristiques de stabilité et de solubilité, et une excellente qualité de sorte qu'aucune matière particulaire insoluble ne se forme lorsque la composition est conservée et fournie dans un contenant en verre, voire en plastique, et également lorsqu'elle est conservée dans ces contenants pendant une longue durée.

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