A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4439 (2006.01) A61K 9/08 (2006.01) A61K 9/19 (2006.01) A61K 47/02 (2006.01) A61K 47/10 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01) A61P 1/00 (2006.01) A61P 1/04 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2419067
An injectable composition comprises a benzimidazole compound having an antiulcer action and a strong alkali (e.g., an alkali metal hydroxide such as sodium hydroxide) in a proportion of about 1 equivalent of the latter relative to 1 mol of the former, and is substantially free from a nonaqueous solvent. The injectable composition may comprise N-methylglucamine, and a saccharide (such as mannitol). The injectable composition may be a freeze-dried preparation. The freeze-dried preparation is dissolvable in or dilutive with a distilled water for injection or an infusion solution without a nonaqueous solvent. The injectable composition is useful as an antiulcer agent.
L'invention concerne des injections contenant environ 1 équivalent de base alcaline forte (par exemple hydroxyde de métal alcalin tel qu'hydroxyde de sodium) par mole d'un composé de benzimidazole possédant un effet antitumoral et sensiblement exempt de solvant non aqueux. Ces injections peuvent en outre contenir de la N-méthylglucamine et des saccharides (mannitol, etc.). Ces injections peuvent être des préparations lyophilisées pouvant être dissoutes ou diluées dans de l'eau distillée à des fins d'injection ou pour des transfusions sans solvant non aqueux. Ces injections sont utiles comme agents antitumoraux.
Asakawa Naoki
Doen Takayuki
Nagao Masao
Takechi Nobuyuki
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
Takeda Pharmaceutical Company Limited
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