Injectable compositions and process for preparation of such...

Details Injectable compositions and process for preparation of such... Injectable compositions and process for preparation of such...

A - Human Necessities

61

K

A61K 9/08 (2006.01)

Patent

CA 2609242

Novel and highly stable injectable pharmaceutical compositions comprising at least one cyclooxygenase-II enzyme (COX-II) inhibitor or non-steroidal anti- inflammatory drug (NSAID) or .COX/LOX inhibitor, or its tautomeric forms, analogues, isomers, polymorphs, solvates, prodrugs or salts thereof as active ingredient suitable for parenteral administration preferably by intramuscular (IM) or intravenous (IV) route; process of preparing such compositions and therapeutic methods of using such compositions are provided. The analgesic and anti-inflammatory injectable compositions of the present invention are very useful in mammals particularly in humans for the treatment of acute painful conditions like one or more of post-operative trauma, pain associated with cancer, sports injuries, migraine headache, neurological pain and pain associated with sciatica and spondylitis, and the like, and/or chronic painful conditions, and/or a variety of painful and inflammatory conditions like postoperative pain, primary dysmenorrhea and painful osteoarthritis, and/or other associated disorders such as inflammation, fever, allergy, or the like.

L'invention concerne des compositions pharmaceutiques injectables, nouvelles et hautement stables, qui comprennent au moins un inhibiteur de la cyclooxygénase-II (COX-II) ou un anti-inflammatoire non stéroïdien (AINS) ou un inhibiteur de COX/LOX ou leurs formes tautomères, analogues, isomères, polymorphes, solvates, promédicaments ou sels de ces derniers comme principe actif approprié à une administration parentérale, de préférence, par voie intramusculaire (IM) ou intraveineuse (IV). L'invention concerne également un procédé de préparation de ces compositions et des méthodes thérapeutiques d'utilisation de ces compositions. Les compositions injectables analgésiques et anti-inflammatoires selon l'invention sont très utiles chez les mammifères, notamment les humains, pour le traitement d'états douloureux aigus tels qu'un ou plusieurs des états suivants : traumatismes postopératoires, douleur associée au cancer, blessures de sport, migraine, douleur neurologique et douleur associée à la sciatique et à la spondylarthrite et à des maladies analogues et/ou des états de douleur chronique et/ou divers états inflammatoires douloureux, tels que la douleur postopératoire, la dysménorrhée primaire et l'arthrose douloureuse, et/ou d'autres troubles associés, tels que l'inflammation, la fièvre, l'allergie ou des états analogues.

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