Injectable cross-linked collagen implant material

Details Injectable cross-linked collagen implant material Injectable cross-linked collagen implant material

C - Chemistry, Metallurgy

07

K

167/103, 167/327

C07K 14/78 (2006.01) A61L 27/24 (2006.01)

Patent

CA 1224210

INJECTABLE CROSS-LINKED COLLAGEN IMPLANT MATERIAL Abstract Cross-linked atelopeptide collagen that is a viscous fluid and substantially free of residual cross-linking agent is prepared by: reconstituting atelopeptide collagen from solution by neutralizing the solution at a reduced temperature and a hypotonic ionic strength; cross-linking the reconstituted fibers with glutaraldehyde at a concentration and under con- ditions that produce a viscous cross-linked collagen; quenching the cross-linking reaction with an amino acid; and separating the viscous cross-linked atelo- peptide collagen from the reaction mixture. This collagen is dispersed in an isotonic aqueous medium for use in dermal augmentation and is injectable and forms implants that have excellent persistence.

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