A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/20 (2006.01) A61L 27/52 (2006.01)
Patent
CA 2524356
A composition for promoting repair of damaged tissues, being a cross-linked alginate solution, which can be maintained in liquid form indefinitely (under constant conditions) and only gels in vivo. This cross-linked alginate solution is an ideal material to be used for tissue repair. Injection of said material into cardiac tissue post-myocardial infarct induced tissue regeneration. The invention provides such injectable solution, as well as compositions and method of preparation thereof. The invention also provides various methods and uses of the cross-linked alginate solution, for cardiac tissue regeneration, induction of neo-vascularization, enhancing SDF-1 expression and guiding stem cell chemotaxis, among others. A kit for tissue repair is also provided.
L'invention concerne une composition, se présentant sous la forme d'une solution d'alginate réticulée, qui permet de favoriser la réparation de tissus endommagés, qui peut être indéfiniment conservée sous forme liquide (dans des conditions constantes) et qui se coagule uniquement in vivo. Cette solution d'alginate réticulée est un matériau idéal destiné à être utilisé à des fins de réparation de tissu. L'injection dudit matériau dans un tissu cardiaque suite à un infarctus du myocarde induit une régénérescence du tissu. L'invention concerne ladite solution injectable ainsi que des compositions et une méthode de préparation correspondantes. L'invention concerne également différentes méthodes et utilisations de la solution d'alginate réticulée, notamment à des fins de régénérescence du tissu cardiaque, d'induction de la néovascularisation, d'amélioration de l'expression de SDF-1 et de guidage du chimiotactisme des cellules souches. L'invention concerne également une trousse de réparation des tissus.
Cohen Smadar
Leor Jonathan
Ben Gurion University Of The Negev Research And Development Auth
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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