A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/34 (2006.01)
Patent
CA 2494342
Injectable depot compositions are provided that include a bioerodible, biocompatible polymer, a solvent having a miscibility in water of less than or equal to 7 wt. % at 25 ~C, in an amount effective to plasticize the polymer and form a gel therewith, a thixotropic agent, and a beneficial agent. The solvent comprises an aromatic alcohol, an ester of an aromatic acid, an aromatic ketone, or mixtures thereof. The compositions have substantially improved the shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.
L'invention concerne des compositions retard injectables comprenant un polymère biocompatible bio-érodable, un solvant présentant une miscibilité avec l'eau inférieure ou égale à 7 % pds à 25 ·C, à une dose suffisante pour plastifier le polymère et former un gel avec ce dernier, un agent thixotropique et un agent traitant. Le solvant comprend un alcool aromatique, un ester d'un acide aromatique, un cétone aromatique ou des mélanges de ceux-ci. Ces compositions présentent un comportement de rhéo-fluidification sensiblement amélioré et une force d'injection réduite, ce qui permet de les implanter facilement par injection sous la surface corporelle du patient.
Chen Guohua
Houston Paul Ricky
Kleiner Lothar Walter
Alza Corporation
Durect Corporation
Smart & Biggar
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