Injectable depot compositions and uses thereof

Details Injectable depot compositions and uses thereof Injectable depot compositions and uses thereof

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2466632

Injectable depot compositions are provided that include a bioerodible, biocompatible polymer, an aromatic alcohol having miscibility in water of less than or equal to 7 wt.% at 25~C, in an amount effective to plasticize the polymer and form a gel therewith, and a beneficial agent. The composition may additionally contain an ester of an aromatic acid, or an aromatic ketone. The compositions are readily implanted beneath a patient's body surface by injection, as the aromatic alcohol not only facilitates solubilization of the polymer, but also acts as a thixotropic agent, substantially increasing the shear thinning behavior of the composition.

Cette invention concerne des composition en dépôt injectables comprenant un polymère bio-érodable et biocompatible, un alcool aromatique dont la miscibilité dans l'eau est inférieure ou égale à 7 % en poids à 25 ·C, en dose efficace suffisante pour plastifier le polymère et former un gel avec ledit polymère, et un agent bénéfique. Cette composition peut renfermer en outre un acide aromatique ou un cétone aromatique. Ces compositions peuvent s'implanter facilement sous la surface du corps d'un patient par injection du fait que l'alcool aromatique non seulement facilite la solubilisation du polymère, mais agit également comme agent thixotropique, ce qui augmente sensiblement la capacité de fluidification de la composition.

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