Injectable depot gel composition and method of preparing the...

A - Human Necessities – 61 – K

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A61K 9/00 (2006.01) A61K 31/70 (2006.01) A61K 38/27 (2006.01) A61K 38/47 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2275587

An injectable depot gel composition containing a polymer, a solvent that can dissolve the polymer and thereby form a viscous gel, a beneficial agent: and an emulsifying agent in the form of a dispersed droplet phase in the viscous gel. The injectable depot gel composition can be prepared by mixing the polymer and the solvent so that the solvent dissolves the polymer and forms a viscous gel. The beneficial agent is dissolved or dispersed in the viscous gel and the emulsifying agent is mixed with the beneficial agent containing viscous gel. The emulsifying agent forms a dispersed droplet phase in the viscous gel to provide the injectable depot gel composition. The injectable depot gel composition can deliver a beneficial agent to a human or animal with a desired release profile.

Une composition de gel injectable à effedt retard contient un polymère, un solvant qui peut dissoudre le polymère et former ainsi un gel visqueux, un agent thérapeutique et un émulsifiant se présentant sous forme d'une phase à goutelettes en dispersion dans le gel visqueux. La composition de gel injectable à effet retard peut être préparée de la manière suivante: on mélange le polymère et le solvant de manière à ce que le solvant dissolve la polymère et forme un gel visqueux. On dissout ou on disperse l'agent thérapeutique dans le gel visqueux puis on mélange l'émulsifiant avec le gel visqueux contenant l'agent thérapeutique. L'émulsifiant forme une phase à gouttelettes en dispersion dans le gel visqueux qui constitue la composition de gel injectable à effet retard. Cette composition de gel injectable à effet retard peut apporter un agent thérapeutique à un homme ou à un animal suivant un schéma de libération désiré.

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