Injectable formulations of nanoparticulate naproxen

Details Injectable formulations of nanoparticulate naproxen Injectable formulations of nanoparticulate naproxen

A - Human Necessities

61

K

A61K 9/51 (2006.01) A61K 9/10 (2006.01) A61K 9/14 (2006.01) A61K 31/192 (2006.01)

Patent

CA 2340221

Described are an injectable formulation of nanoparticulate naproxen that produces minimal or no pain or burning sensation upon administration, and methods of making and using such a formulation. The injectable formulation comprises nanoparticulate naproxen having a povidone polymer adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 600 nm.

La présente invention concerne une formulation injectable de nanoparticules de naproxène dont l'administration se fait en l'absence partielle ou totale de douleur ou de sensation de brûlure. L'invention concerne également un procédé de fabrication ainsi que les modalités d'utilisation d'une telle formulation. En l'occurrence, cette formulation injectable comprend des nanoparticules de naproxène à la surface desquelles est adsorbée une quantité de povidone suffisante pour conserver aux particules un calibre effectif moyen n'excédant pas environ 600 nm.

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