Injectable hyaluronate-sulfated polysaccharide conjugates

Details Injectable hyaluronate-sulfated polysaccharide conjugates Injectable hyaluronate-sulfated polysaccharide conjugates

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 9/14 (2006.01) A61K 47/36 (2006.01) A61L 27/20 (2006.01)

Patent

CA 2377529

An injectable composition is provided for promoting bone and/or cartilage growth comprising hyaluronic acid cross-linked to sulfated polysaccharide through linking groups. The linking groups are diamines or amino polyalkylene glycols. The sulfated polysaccharide binds growth factors suitable for promoting tissue growth at the site of application of the composition.

L'invention concerne une composition injectable servant à activer la croissance osseuse et/ou de cartilage, qui comporte un acide hyaluronique réticulé à un polysaccharide sulfaté par l'intermédiaire de groupes de liaison. Les groupes de liaison sont des diamines ou des amino polyalkylène glycols. Le polysaccharide sulfaté se lie à des facteurs de croissance qui activent la croissance tissulaire au site d'application de la composition.

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