Injectable hydrogel compositions

Details Injectable hydrogel compositions Injectable hydrogel compositions

A - Human Necessities

61

L

A61L 27/00 (2006.01) A61L 27/38 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2223932

Slowly polymerizing hydrogels are provided which are useful as a means of delivering large numbers of isolated cells via injection. The gels promote engraftment and provide three-dimensional templates for new cell growth. The resulting tissue is similar in composition and histology to naturally occurring tissue. This method can be used for a variety of reconstructive procedures, including custom molding of cell implants to reconstruct three- dimensional tissue defects, as well as implantation of tissues generally. The polymers permit construction of muscle and cartilage tissues which are useful to repair defects such as reflux and incontinence.

Cette invention se rapporte à des hydrogels à polymérisation lente, qui sont utiles comme moyen pour administrer de grandes quantités de cellules isolées par injection. Ces gels stimulent la prise de greffes et fournissent des matrices tridimensionnelles pour la croissance de nouvelles cellules. Le tissu qui en résulte est de composition et d'histologie similaires à celles des tissus existants à l'état naturel. Ce procédé peut être utilisé pour une grande variété de techniques de reconstruction, y compris le moulage personnalisé d'implants cellulaires destinés à reconstruire des structures tissulaires tridimensionnelles lésées, ainsi que l'implantation de tissus, d'une manière générale. Ces polymères permettent la construction de tissus musculaires et cartilagineux qui sont utiles pour réparer des défauts tels que le reflux et l'incontinence.

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