Injectable hydrogel microspheres from aqueous two-phase system

Details Injectable hydrogel microspheres from aqueous two-phase system Injectable hydrogel microspheres from aqueous two-phase system

A - Human Necessities

61

K

A61K 9/50 (2006.01) A61K 9/10 (2006.01) A61K 38/19 (2006.01)

Patent

CA 2513483

Injectable hydrogel microspheres are prepared by forming an emulsion where hydrogel precursors are in a disperse aqueous phase and polymerizing the hydrogel precursors. In a preferred case, the hydrogel precursors are poly(ethylene glycol) diacrylate and N-isopropylacrylamide and the continuous phase of the emulsion is an aqueous solution of dextran and a dextran solubility reducer. The microspheres will load protein, e.g., cytokines, from aqueous solution.

La présente invention concerne des microsphères hydrogel injectables qu'on prépare en formant une émulsion dans laquelle des précurseurs hydrogel sont dans une phase aqueuse dispersée et en polymérisant ces précurseurs hydrogel. Dans un mode de réalisation préféré de l'invention, les précurseurs hydrogel sont poly(éthylène glycol) diacrylate et N-isopropylacrylamide et la phase continue de l'émulsion est une solution aqueuse de dextrane et un réducteur de solubilité de dextrane. Ces microsphères porteront une protéine, par exemple des cytokines, de la solution aqueuse.

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