A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/30 (2006.01) A61K 47/36 (2006.01) A61K 47/42 (2006.01) A61P 41/00 (2006.01) A61P 43/00 (2006.01) C08J 3/24 (2006.01)
Patent
CA 2740136
The present invention discloses an injectable in-situ crosslinked hydrogel and its preparation method. The preparation method is as below: Filling the crosslinking active solution of at least one kind of the biocompatible macromolecules containing more than two thiol groups on the side chains into an injectable container and sealing it, and forming the in-situ disulfide-bond crosslinked hydrogel under the action of the dissolved oxygen; through controlling such parameters as partial pressure of oxygen gas, temperature and time, regulating concentration of the oxygen dissolved in the crosslinking active solution, and optimizing the gelation process and the gel properties. The present invention further relates to application of the injectable in-situ crosslinked hydrogel in pharmaceutics or surgery. The present invention has many advantages, such as no need for a crosslinking agent, simple preparation process, convenient application, containing no impurities, good biocompatibility, no toxic and side effect, and wide application in the medical science.
Linvention concerne un hydrogel injectable réticulé sur place et sa méthode de préparation. La méthode consiste: à remplir la solution active réticulée d'au moins une macromolécule biocompatible dans un contenant d'injection, ladite macromolécule présentant plus de deux groupes sulfhydryles dans sa chaîne latérale; à former l'hydrogel réticulé sur place par disulfure par l'action de l'oxygène dissous. Le contrôle des paramètres tels que la pression différentielle de l'oxygène, la température, la durée, etc., permet de régler la concentration de l'oxygène dissous et d'optimiser le processus de gélification et les propriétés du gel. L'invention concerne en outre l'utilisation de l'hydrogel injectable réticulé sur place dans des médicaments ou lors d'opérations chirurgicales.
Bioregen Biomedical (changzhou) Co. Ltd.
Gowling Lafleur Henderson Llp
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