A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 9/10 (2006.01) A61K 47/34 (2006.01) A61L 31/00 (2006.01)
Patent
CA 2494400
Injectable depot compositions are provided that include a polymer matrix having a plurality of bioerodible, biocompatible polymers wherein each polymer of the plurality of polymers has a specified weight average molecular weight; and the polymer matrix has a broad molecular weight distribution of the plurality of polymers; a solvent having a miscibility in water of less than or equal to 7 wt.% at 25~C, in an amount effective to plasticize the polymer and form a gel therewith; and a beneficial agent. The compositions are have substantially improved the shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection. The most preferred polymer matrix is made of poly (lactide-co-glycolide) copolymers, commonly referred to as PLGA. The most preferred solvents are derivatives of benzoic acid, such as benzylbenzoate.
L'invention concerne des compositions de dépôt injectables comprenant une matrice polymère ayant une pluralité de polymères bioérodables et biocompatibles, chaque polymère ayant un poids moléculaire moyen spécifié ; et la matrice polymère ayant une distribution de poids moléculaire large de la pluralité de polymère ; un solvant dont la capacité hydromiscible est inférieure ou égale à 7 % en poids à 25 ·C, selon une quantité efficace pour plastifier le polymère et former un gel ; ainsi qu'un agent bénéfique. Les compositions améliorent sensiblement la fluidification par cisaillement et réduisent la force d'injection, elles sont donc prêtes à être implantées dans la surface corporelle d'un patient par injection.
Chen Guohua
Houston Paul
Kleiner Lothar
Wright Jeremy
Alza Corporation
Durect Corporation
Smart & Biggar
LandOfFree
Injectable multimodal polymer depot compositions and uses... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Injectable multimodal polymer depot compositions and uses..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Injectable multimodal polymer depot compositions and uses... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1693243