Injectable pharmaceutical suspension in a two-chamber vial

A - Human Necessities – 61 – J

Patent

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A61J 1/06 (2006.01) A61K 47/02 (2006.01) A61K 47/10 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01) A61K 47/32 (2006.01) A61K 31/57 (2006.01)

Patent

CA 2494825

An article of manufacture is provided comprising a vial having (a) a first chamber that is substantially filled with an injectable pharmaceutical formulation; (b) a second chamber that is substantially empty but for a gaseous medium; (c) a septum, impermeable to the gaseous medium, separating the first and second chambers; and (d) actuating means effective to bring the formulation and the gaseous medium into contact by breach of the septum such that the gaseous medium acts as an effective headspace for agitation of the formulation. The formulation comprises an aqueous medium, a drug in solid particulate form in a therapeutically effective amount suspended in the medium, and one or more wetting and/or suspending agents in an amount effective to provide controlled flocculation of the drug, at least one ingredient of the formulation being susceptible to oxidative degradation.

L'invention concerne un article comprenant une fiole comportant : a) une première chambre qui est sensiblement remplie d'une composition pharmaceutique injectable ; b) une seconde chambre qui est sensiblement vide mais qui est conçu pour un milieu gazeux ; c) un septum imperméable au milieu gazeux, séparant les première et seconde chambres ; et d) des moyens d'actionnement permettant de mettre en contact la composition et le milieu gazeux par percée du septum de sorte que le milieu gazeux agit comme un espace libre pour l'agitation de la composition. La composition comprend un milieu aqueux, un médicament sous forme particulaire solide en une quantité thérapeutiquement efficace suspendue dans le milieu, et un ou plusieurs agents mouillants et/ou des agents de mise en suspension en une quantité efficace pour obtenir une floculation contrôlée du médicament. Au moins un ingrédient de la formulation est susceptible d'effectuer une dégradation par oxydation.

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