Injectable polymer-lipid blend for localized drug delivery

A - Human Necessities – 61 – K

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Details

A61K 47/36 (2006.01) A61K 9/00 (2006.01) A61K 31/337 (2006.01) A61K 47/08 (2006.01) A61K 47/12 (2006.01) A61K 47/24 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2690771

An injectable polymer-lipid blend is provided as a localized drug delivery system for a pharmaceutically active agent. The blend may be prepared from a chitosan-based material, fatty acid and phospholipid. The chitosan-based material may be a water soluble chitosan derivative. The fatty acid may be a fatty acid or a fatty aldehyde, such as laurinaldehyde, having an acyl chain length of C8-C16. The rheological properties of the blend relates to the ratio of the components and to the acyl chain length of the fatty acid. The injectable system is well suited for the delayed release of pharmaceutically active agents in the treatment of cancer and other diseases requiring localized drug delivery.

La présente invention concerne un mélange polymère-lipide injectable en tant que système de délivrance localisée de médicament pour un agent actif sur le plan pharmaceutique. Le mélange peut être préparé à partir d'une substance à base de chitosane, d'acide gras et de phospholipide. La substance à base de chitosane peut être un dérivé du chitosane hydrosoluble. L'acide gras peut être un acide gras ou un aldéhyde gras, tel que le lauryl-aldéhyde, ayant une longueur de chaîne acyle de C8 à C16. Les propriétés rhéologiques du mélange sont associées au rapport des composants et à la longueur de la chaîne acyle de l'acide gras. Le système injectable est bien adapté pour la libération retardée d'agents actifs sur le plan pharmaceutique dans le traitement du cancer et d'autres maladies nécessitant une délivrance localisée de médicament.

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