Injectable preparations containing cephalosporin medicament

A - Human Necessities – 61 – K

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A61K 31/545 (2006.01) A61K 47/00 (2006.01)

Patent

CA 2026516

A preparation containing a cephalosporin medicament is disclosed. The preparation comprises a cephalosporin derivative represented by the following formula: (see fig. I) namely, 7.beta.-[2-(5-amino-1,2,4-thiadiazol-3-yl)-(Z)-2- fluoromethoxyiminoacetamido]-3-[(E)-3-(carbamoylmethyl- ethylmethylammonio)-1-propen-1-yl]-3-cephem-4- carboxylate or a pharmaceutically acceptable salt thereof salt, lactose, citric acid or a sodium salt thereof, and arginine or a hydrochloride thereof; or the cephalosporin derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof, lactose, citric acid or a sodium salt thereof, and sodium chloride.

Préparation renfermant un médicament à base d'un dérivé de la céphalosporine, représenté par la formule (voir fig. I) 7bêta.-[2-(5-amino-1,2,4-thiadiazol-3-yl)-(Z)-2- fluorométhoxyimino-acétamido]-3-[(E)-3-(carbamoylméthyl- éthylméthylammonio)-1-propén-1-yl]-3-céphème-4-carboxylate ou un sel de ce composé, acceptable en pharmacie, du lactose, de l'acide citrique ou un sel sodique de ce dernier, ainsi que de l'arginine ou un chlorhydrate de celle-ci, ou le dérivé de céphalosporine représenté par la formule (I) ou un sel de ce dérivé, acceptable en pharmacie, du lactose, de l'acide citrique ou un sel sodique de celui-ci, et du chlorure de sodium.

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