Injectable propofol formulations

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/05 (2006.01) A61K 31/225 (2006.01) A61K 31/565 (2006.01) A61P 23/00 (2006.01)

Patent

CA 2338684

The invention provides injectable formulations of propofol using N- methylpyrrolidone or 2-pyrrolidone as a solvent, Formulations of the invention are useful in all medical and veterinary indications when propofol its presently used. In addition, combinations of propofol and an appropriate toxin are useful for fast-acting, humane veterinary euthanasia injectable compositions. N-methylpyrrolidone-propylene glycol formulations are inherently bacteriostatic, thereby eliminating one of the problems associated with currently available formulations.

L'invention concerne des formulations injectables de propofol comprenant du N-méthylpyrrolidone ou du 2-pyrrolidone en tant que solvant. Ces formulations sont utiles dans toutes les indications médicales et vétérinaires comprenant l'utilisation de propofol. Les combinaisons de propofol avec une toxine appropriée sont en outre utiles comme compositions d'euthanasie vétérinaires injectables sans douleur. Les formulations N-méthylpyrrolidione-propylène glycol ont des propriétés bactériostatiques inhérentes, ce qui permet d'éliminer un des problèmes rencontrés avec les formulations actuellement disponibles.

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