Injectable solution and process for preparing same

Details Injectable solution and process for preparing same Injectable solution and process for preparing same

A - Human Necessities

61

K

167/122

A61K 31/445 (2006.01) A61K 9/08 (2006.01) A61K 31/40 (2006.01) A61K 31/475 (2006.01) A61K 47/14 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2029368

The invention relates to novel, parenterally useful, stable aqueous pharmaceutical compositions, mainly injectable solutions containing a bis-indole alkaloid. The compositions contain the zinc complex of a bis-indole alkaloid, preferably vincristine, vinblastine or 5'-nor-dihydrovinblastine together with a bivalent metal gluconate and a preserving agent dissolved in a mono- or polyhydric alcohol. The invention further relates to a process for the preparation of the above compositions. The composition according to the invention can be utilized for the parenteral administration of bis-indole alkaloids in the cancer chemotherapy.

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