Inositol phosphate analogues

Details Inositol phosphate analogues Inositol phosphate analogues

C - Chemistry, Metallurgy

07

F

167/101, 167/250

C07F 9/177 (2006.01) A61K 31/66 (2006.01)

Patent

CA 1309415

ABSTRACT Novel inositol phosphorothioates, useful for conducting research into the biochemistry of inositol phosphate esters, have the general formula I: C6H6 (OH)n [(OPO2S)2]m [OPO2O)2-]6-m-n (I) in which n is zero or an integer from 1 to 5 and, m is an integer from 1 to 6. They may be prepared by a method comprising reacting an inositol derivative having the general formula II: C6H6 (OB)n [OP(OCH2CH2CN)2]6-n (II) in which n is zero or an integer from 1 to 5 and B represents a hydroxyl-protecting group, with a solution of elemental sulphur, which may or may not be radioactive, in a solvent therefor, and removing the hydroxyl-protecting groups from the product of the reaction. Phosphate esters may be prepared by oxidizing the compound of formula II with an organic peroxide.

561215

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