Inositol phosphoglycan derivatives and their medical uses

C - Chemistry – Metallurgy – 07 – H

Patent

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C07H 15/207 (2006.01) A61K 31/70 (2006.01) C07H 3/04 (2006.01) C07H 3/06 (2006.01) C07H 11/04 (2006.01) C07H 15/256 (2006.01)

Patent

CA 2433854

Compounds having a mimetic or antagonistic property of an inositol phosphoglycan, and the uses of these compounds are disclosed, together with the use, e.g. to treat a condition ameliorated by administration of an IPG second messenger or an IPG antagonist thereof. Preferred compounds of the invention are based on the substituted cyclitols, and in particular cyclitols linked to a sugar moiety where the molecule is substituted with a negatively charged group such as phosphate.

L'invention concerne, d'une part, des composés présentant une propriété mimétique ou antagoniste d'un inositol phosphoglycane et, d'autre part, les diverses utilisations de ces composés, y compris leur utilisation, par exemple, pour le traitement d'une affection améliorée par administration d'un second messager IPG ou d'un antagoniste de l'IPG. Les composés recommandés dans cette invention sont fondés sur les cyclitols substitués, et plus particulièrement, les cyclitols liés à un fragment de sucre dans lequel la molécule est substituée à l'aide d'un groupe à charge négative, tel que le phosphate.

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