Inosose derivatives, production and use thereof

Details Inosose derivatives, production and use thereof Inosose derivatives, production and use thereof

C - Chemistry, Metallurgy

07

C

260/327.3, 260/5

C07C 49/753 (2006.01) C07C 45/29 (2006.01) C07C 45/65 (2006.01) C07C 45/67 (2006.01) C07C 49/255 (2006.01) C07C 49/517 (2006.01) C07C 215/44 (2006.01) C07D 309/12 (2006.01) C07D 339/08 (2006.01)

Patent

CA 1293259

Abstract of the Disclosure Disclosed is a novel inosose compound represented by the general formula: Image wherein X1 and X2 are both halogen; X1 is hydrogen and X2 is halogen; or X1 is -SQ1 and X2 is -SQ2 (each of Q1 and Q2 is lower alkyl or Q1 and Q2 may form lower alkylene), R1 is a protective group for hydroxyl and Y is =O, =N-Z (Z is hydroxyl which may be protected) or Image (A is hydrogen or an amine residue), particularly to the compound wherein the symbol Y is oxygen. The inosose compound is useful as intermediates for production of valiolamine and the N-substituted derivatives thereof, which have potent .alpha.-glucosidase inhibiting activities and are useful as preventives or therapeutics for symptoms of hyperglycemia and various diseases derived therefrom in human and animals, such as diabetes, obesity and hyperlipemia.

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