Inotropic and diuretic effects of exendin and glp-1

Details Inotropic and diuretic effects of exendin and glp-1 Inotropic and diuretic effects of exendin and glp-1

A - Human Necessities

61

K

A61K 38/26 (2006.01) A61K 38/17 (2006.01) A61P 7/10 (2006.01)

Patent

CA 2320371

Methods for increasing urine flow are disclosed, comprising administration of an effective amount of GLP-1, an exendin, or an exendin or GLP-1 agonist. Methods for increasing urinary sodium excretion and decreasing urinary potassium concentration are also disclosed. The methods are useful for treating conditions or disorders associated with toxic hypervolemia, such as renal failure, congestive heart failure, nephrotic syndrome, cirrhosis, pulmonary edema, and hypertension. The present invention also relates to methods for inducing an inotropic response comprising administration of an effective amount of GLP-1, an exendin, or an exendin or GLP-1 agonist. These methods are useful for treating conditions or disorders that can be alleviated by an increase in cardiac contractility such as congestive heart failure. Pharmaceutical compositions for use in the methods of the invention are also disclosed.

L'invention porte sur des procédés favorisant le débit urinaire consistant à administrer une quantité efficace de GLP-1 et d'extendine, ou d'un agoniste de GLP-1 ou d'extendine, et sur des procédés renforçant l'excrétion urinaire du sodium et diminuant la concentration urinaire du potassium. Ces procédés s'avèrent utiles dans le traitement d'états ou de troubles associés à l'hypervolémie toxique tels que l'insuffisance rénale, l'insuffisance cardiaque globale, le syndrome néphrotique, la cirrhose, l'oedème pulmonaire et l'hypertension. L'invention porte en outre sur des procédés d'induction d'une réponse inotropique consistant en l'administration d'une quantité efficace de GLP-1 et d'extendine, ou d'un agoniste de GLP-1 ou d'extendine. Ces procédés s'avèrent utiles dans le traitement d'états ou de troubles susceptibles d'être soulagés par un accroissement de la contractilité du coeur tels que l'insuffisance globale. L'invention porte également sur des préparations pharmaceutiques associées aux susdits procédés.

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