Insect g protein-coupled receptor genes and uses thereof

Details Insect g protein-coupled receptor genes and uses thereof Insect g protein-coupled receptor genes and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01N 63/00 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/82 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2459661

The present invention provides isolated nucleic acids encoding insect G protein-coupled receptor (GPCR) polypeptides, isolated insect GPCR polypeptides, and uses thereof. Further provided are recombinant proteins and methods for identifying inhibitors to these proteins. The disclosed insect GPCR nucleic acids and polypeptides can be used in screening assays to identify modulating compounds. Protein inhibitors active in the methods disclosed herein are useful as insecticidal, ectoparasiticidal, antiparasitic, anthenenthic and acaracidal agents.

La présente invention concerne des acides nucléiques isolés codant pour des polypeptides du récepteur couplé aux protéines G (GPCR), des polypeptides GPCR d'insectes isolés, ainsi que leurs utilisations. L'invention concerne également des protéines recombinantes et des méthodes d'identification d'inhibiteurs de ces protéines. Les acides nucléiques et les polypeptides GPCR peuvent être utilisés dans des méthodes de criblage en vue d'une identification de composés modulateurs. Les inhibiteurs de protéines actifs dans les méthodes de l'invention sont utiles comme agents insecticides, ectoparasitaires, antiparasitaires, anthelminthiques et acaricides.

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