Insect neuropeptides genes and peptides

Details Insect neuropeptides genes and peptides Insect neuropeptides genes and peptides

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01N 63/02 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/435 (2006.01)

Patent

CA 2250128

The DNA encoding novel peptides isolated from the blowfly Calliphora vomitoria of the callatostatin class of insect neuropeptides has been isolated. The DNA which encodes these novel peptides also encodes the other known Leucallatostatin peptides that have already been isolated from C. vomitoria. The homologues of this gene have also been isolated from Helicoverpa armigera and the Australian sheep blowfly Lucilia cuprina. The peptides have inhibitory effects on gut motility in the blowfly C. vomitoria and may have allatostatic effects in cockroaches. The peptides have application as insecticides and the DNA encoding the peptides may be inserted into a baculovirus for use as an insecticide against the pest species Cydia pomonella or Helicoverpa armigera, or other target organisms. Variants of these peptides have also been isolated from Cydia pomonella, Helicoverpa armigera and Pteronida salicis.

On a isolé sur la mouche à viande Calliphora vomitoria de nouveaux peptides de codage de l'ADN appartenant à la classe callatostatine de neuropeptides d'insectes. L'ADN qui code ces nouveaux peptides code aussi les autres peptides de Leu-callatostatine qui ont déjà été isolés sur C. vomitoria. Les homologues de ce gène ont été également isolés sur Helicoverpa armigera et sur Lucilia cuprina, autrement dit la lucilie. Les peptides inhibent la motilité du tube digestif de C. vomitoria et pourraient produire des effets allatostatiques chez les cafards. Les peptides peuvent servir d'insecticides. L'ADN qui code ces peptides peut être introduit dans un baculovirus pour servir d'insecticide contre l'espèce nuisible Cydia pomonella ou Helicoverpa armigera ou contre d'autres organismes. Des variantes de ces peptides ont également été isolées sur Cydia pomonella, Helicoverpa armigera et Pteronida salicis.

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