C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01N 37/18 (2006.01) A01N 37/46 (2006.01) A01N 63/00 (2006.01) A01N 63/02 (2006.01) C07K 14/435 (2006.01)
Patent
CA 2213443
This invention relates to the purification of a family of insecticidally effective peptides isolated from the spider, Calisoga sp., characterized by their neurotoxic effect on insect pest and low mammalian toxicity. The cDNA sequences for three of these peptides have been isolated, and the complete coding sequence is provided. This invention also discloses methods for producing recombinant peptides, as well as methods of utilizing these peptides as insecticidal agents.
L'invention concerne la purification d'une famille de peptides présentant une activité insecticide et isolés à partir de l'araignée Calisoga, caractérisés par leur effet neurotoxique sur les insectes parasites et une faible toxicité pour les mammifères. On a isolé les séquences d'ADNc pour trois de ces peptides et établi la séquence codante complète. Cette invention concerne également des procédés de production de peptides recombinés, ainsi que des procédés d'utilisation desdits peptides en tant qu'agents insecticides.
Johnson Janice H.
Kral Robert M.
Krapcho Karen
Nps Pharmaceuticals Inc.
Ridout & Maybee Llp
LandOfFree
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