Insoluble gas-filled microspheres containing a hydrophobic...

A - Human Necessities – 61 – K

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A61K 49/00 (2006.01) A61K 49/22 (2006.01)

Patent

CA 2220706

The present invention relates to a process for making insoluble gas-filled, pressure-resistant microspheres containing a liquid or solid hydrophobic barrier within the microsphere shell, and products of this process. This barrier serves to decrease the rate of gas exchange between the microsphere and the aqueous environment surrounding the microsphere and thus enhances resistance to pressure due to gas exchange.

La présente invention concerne un processus de fabrication de micro-sphères insolubles remplies de gaz, résistantes à la pression et contenant une barrière hydrophobe liquide ou solide dans l'enveloppe de ladite micro-sphère, ainsi que les produits obtenus par ce processus. Cette barrière permet de diminuer le taux d'échange gazeux entre une micro-sphère et le milieu aqueux qui l'entoure, et d'accroître ainsi sa résistance à la pression due à l'échange gazeux.

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