Instant oral-release capsule containing nifedipine

A - Human Necessities – 61 – K

Patent

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A61K 31/44 (2006.01) A61K 9/00 (2006.01) A61K 9/48 (2006.01) A61K 9/66 (2006.01) A61K 47/34 (2006.01)

Patent

CA 1312549

A b s t r a c t The invention concerns an instant oral-release capsule containing an aqueous or aqueous alcoholic solution of nifedipine, containing a polyalkylene glycol and a polyoxyethylene ester component, the amount of the ester component in the solution being sufficient to prevent precipitation of nifedipine in the mouth of a patient after release of the solution from the capsule. Preferably, the ester component. is an ethoxylated hydrogenated castor oil Cremophor* RH40. The solution may further contain a second glycol component, especially glycerol. * Trade-Mark

583042

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