G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/49 (2006.01) G01N 3/08 (2006.01) G01N 33/487 (2006.01)
Patent
CA 2127454
Intermittent application and removal of a compressive force on a blood sample (8) positioned between a pair of plates (12 and 14) throughout clot formation and dissolution provides a standard for using voltage output from a transducer (22) to determine force and elastic modulus parameters. Force development arises from the internal actions of the platelets during clot retraction. Elastic modulus provides a measure of the stiffness of the clot. Clotting can be measured as an increase in force development and clot elastic modulus. Clot dissolution can be determined by a dramatic decrease in force development and in elastic modulus. Providing the blood sample with a clot dissolving agent such as tPA allows determining the fibrinolytic potential of whole blood and, thus, aids in identifying patients at risk for thrombosis due to a decreased ability to dissolve clots. Clot elastic modulus provides a measure of erythrocyte flexibility.
Center For Innovative Technology
Macrae & Co.
Virginia Commonwealth University Intellectual Property Foundatio Inc.
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