Insulin c-peptides

Details Insulin c-peptides Insulin c-peptides

A - Human Necessities

61

K

A61K 38/28 (2006.01) A61K 38/08 (2006.01) A61P 3/10 (2006.01) A61P 5/50 (2006.01) C07K 7/06 (2006.01) C07K 14/62 (2006.01)

Patent

CA 2266416

The present invention relates to a peptide being a fragment of the human insulin C-peptide, said peptide comprising the sequence ELGGGPGAG or a fragment thereof, or the sequence EGSLQ or a fragment thereof, and having the ability to stimulate Na+K+ATPase activity. Further provided are biomimetic organic compounds exhibiting activation of Na+K+ATPase activity and/or cellular binding to renal tubule cells and fibroblasts at at least the level exhibited by the aforementioned peptides or their fragments. Such peptides and compounds have utility in combatting diabetes and diabetic complications, or for stimulating Na+K+ATPase activity.

L'invention concerne un peptide qui est un fragment du peptide C de l'insuline humaine. Ce peptide, qui comprend la séquence ELGGGPGAG ou un de ses fragments, ou bien la séquence EGSLQ ou un de ses fragments, est capable de stimuler l'activité Na<+>K<+>ATPase. L'invention concerne également des composés organiques biomimétiques qui favorisent l'activité Na<+>K<+>ATPase et/ou la fixation cellulaire sur les cellules des tubules rénaux et les fibroblastes au moins au même taux que les peptides ou leurs fragments mentionnés ci-dessus. Ces peptides et composés sont utiles pour lutter contre le diabète et ses complications, ou pour stimuler l'activité Na<+>K<+>ATPase.

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