Insulin derivatives, process for their preparation, their...

Details Insulin derivatives, process for their preparation, their... Insulin derivatives, process for their preparation, their...

C - Chemistry, Metallurgy

07

K

195/128.3, 530/7

C07K 14/62 (2006.01) A61K 38/28 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2029289

- 1 - Abstract of the disclosure: Novel insulin derivatives, process for their preparation, their use and a pharmaceutical preparation containing them Novel insulin derivatives of the formula III Image (III) in which a) R30 + R31 together = OH or b) R30 = a radical of a neutral, genetically encodable L-amino acid and R31 = OH or a physiologically acceptable organic group of basic character having up to 50 carbon atoms, whose synthesis involves 0 to 3 .alpha.-amino acids and whose optional terminal carboxyl function can be present free, as an ester function, as an amide function, as a lactone or reduced to CH2OH, and c) RA-1 = a radical of a genetically encodable L-amino acid or a physiologically acceptable organic group having up to 50 carbon atoms, with the exception of the case in which, at the same time, R30 = Ala, R31 = OH, RA-1 = Lys or Arg and the A and B chain are the sequences of bovine insulin, and its physiologically tolerable salts. - 2 - The compounds are suitable for the treatment of diabetes mellitus, have a sustained action profile and are very well tolerated.

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