Insulin derivatives with increased zinc binding

Details Insulin derivatives with increased zinc binding Insulin derivatives with increased zinc binding

C - Chemistry, Metallurgy

07

K

C07K 14/62 (2006.01) A61K 38/28 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2207078

Insulin derivatives with increased zinc binding where Z is a histidine residue or a peptide having 2 to 35 genetically encodable amino acid residues, containing 1 to 5 histidine residues, are suitable for the production of pharmaceutical preparations for the treatment of diabetes. Insulins of the formula I form complexes with zinc, containing an insulin hexamer and approximately 5 to 9 mol of zinc per hexamer.

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