Insulin-like growth factor binding protein-4 protease

Details Insulin-like growth factor binding protein-4 protease Insulin-like growth factor binding protein-4 protease

A - Human Necessities

61

K

A61K 39/395 (2006.01) C12N 9/00 (2006.01) C12N 9/64 (2006.01) C12Q 1/00 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2367360

Methods for screening for altered focal proliferation states in non-pregnant patients, which include detecting levels of pregnancy-associated plasma protein-A (PAPP-A), are described. Methods for identifying agents that alter the protease activity of PAPP-A, and pharmaceutical compositions and medical devices that include such agents are also described.

Cette invention concerne des procédés qui permettent de cribler et de détecter des états de prolifération focale altérés chez des patientes non enceintes, lesquels procédés consistent à mesurer les niveaux de protéine A du plasma associée à la grossesse (PAPP-A). Cette invention concerne également des procédés permettant d'identifier les agents qui altèrent l'activité de la protéase de PAPP-A, ainsi que des compositions pharmaceutiques et des dispositifs médicaux où l'on utilise ces agents.

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