Insulin-like growth factor (igf) i mutant variants

Details Insulin-like growth factor (igf) i mutant variants Insulin-like growth factor (igf) i mutant variants

C - Chemistry, Metallurgy

07

K

C07K 14/65 (2006.01) A61K 38/30 (2006.01) A61P 13/12 (2006.01)

Patent

CA 2356109

IGF-I variants having an alanine, glycine, or serine amino acid residue at position 16, 25, 49 or at positions 3 and 49 of native-sequence IGF-I are provided that are useful to treat a disorder characterized by dysregulation of the GH/IGF axis in a mammal, such as a renal disorder.

L'invention concerne des variants de IGF-I qui possèdent un reste d'acide aminé d'alanine, glycine, ou sérine à l'emplacement 16, 25, 49 ou aux emplacements 3 et 49 de la séquence native de l'IGF-I. Lesdits variants sont utilisés pour traiter un trouble, tel qu'un trouble rénal, caractérisé par une dérégulation de l'axe hormone de croissance/IGF, chez un mammifère.

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