Insulin-like growth factor (igf) i mutant variants

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/65 (2006.01) A61K 38/30 (2006.01) A61P 5/02 (2006.01)

Patent

CA 2356257

IGF-I and insulin variants are provided that selectively bind to IGFBP-1 or IGFBP-3. These agonist variants are useful, for example, to improve the half- lives of IGF-I and insulin, respectively.

On décrit des variants de IGF-1 et d'insuline qui se lient sélectivement à IGFBP-1 ou IGFBP-3. Ces variants d'agoniste sont utiles par exemple pour améliorer les demi-vies de IGF-1 et de l'insuline respectivement.

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