Insulin-like growth factor ii antisense oligonucleotide...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/11 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2326825

This invention relates to oligonucleotides complementary to the IGF-II genes which modulate tumor cell growth in mammals. This invention is also related to methods of using such compounds in inhibiting the growth of tumor cells in mammals. This invention also relates to pharmaceutical compositions comprising a pharmaceutically acceptable excipient and an effective amount of a compound of this invention.

L'invention concerne des oilgonucléotides complémentaires des gènes d'IGF-II qui modulent la croissance des cellules tumorales chez les mammifères. Elle porte aussi sur des procédés d'utilisation desdits composés dans l'inhibition de la croissance des cellules tumorales chez les mammifères ainsi que sur des compositions pharmaceutiques comprenant un excipient, acceptable au plan pharmaceutique, d'un composé de l'invention.

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