Insulin-oligomer conjugates, formulations and uses thereof

Details Insulin-oligomer conjugates, formulations and uses thereof Insulin-oligomer conjugates, formulations and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/62 (2006.01)

Patent

CA 2580313

The invention provides a complex including a cation and an insulin compound conjugate. The insulin compound conjugate includes insulin compound, such as human insulin or an analog thereof, conjugated to a modifying moiety, such as a polyethylene glycol moiety. The invention also includes solids and pharmaceutical compositions including such complexes, methods of making such complexes, and methods of using such complexes in the treatment of insulin compound deficiencies and other ailments. Further, the invention includes novel insulin compound conjugates and modifying moieties for use in making novel insulin compound conjugates. The invention also includes fatty acid compositions for administration of of pharmaceutical agents, such as the novel insulin compound conjugates, and/or the cation-insulin compound conjugate complexes of the invention.

La présente invention concerne un complexe comprenant un cation et un conjugué de composé d'insuline. Le conjugué de composé d'insuline comprend un composé d'insuline, tel qu'une insuline humaine ou un analogue de celle-ci, conjugué à un groupe de modification, tel qu'un groupe polyéthylène glycol. Cette invention concerne également des solides et des compositions pharmaceutiques comprenant de tels complexes, des procédés pour fabriquer de tels complexes, ainsi que des procédés pour utiliser ces complexes dans le cadre du traitement de déficiences de composé d'insuline et d'autres troubles. De plus, cette invention concerne de nouveaux conjugués de composé d'insuline et des groupes de modification utilisés pour fabriquer de nouveaux conjugués de composé d'insuline. Cette invention concerne aussi des compositions d'acides gras utilisées pour administrer des agents pharmaceutiques, tels que les nouveaux conjugués de composé d'insuline, et/ou les complexes cation-conjugué de composé d'insuline.

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