Insulin precursors, process for their preparation and...

Details Insulin precursors, process for their preparation and... Insulin precursors, process for their preparation and...

C - Chemistry, Metallurgy

12

N

195/1.22, 195/1.

C12N 15/17 (2006.01) C07K 14/39 (2006.01) C07K 14/62 (2006.01) C12N 15/81 (2006.01)

Patent

CA 1340823

Novel human insulin precursors of the formula B-X-Y-A, wherein X and Y are each lysine or arginine, are prepared by culturing a yeast host transformed with a replicable expression vehicle capable of expressing a DNA-sequence encoding the human insulin precursors in yeast. Human insulin is prepared by recovery of the insulin precursors from the culture medium and converting the insulin precursors into human insulin by enzymatic treatment.

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