C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 167/139,
C12N 15/17 (2006.01) A61K 39/395 (2006.01) A61K 39/44 (2006.01) C07H 21/04 (2006.01) C07K 14/62 (2006.01) C07K 14/72 (2006.01) C07K 16/20 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1341149
Insulin receptor is purified in accordance with this invention to a level sufficient to enable amino acid sequencing thereof. DNA encoding insulin receptor is provided, as well as methods for synthesizing insulin receptor or its mutant in heterologous host cells transformed with vectors containing such DNA. Knowledge of the amino acid sequence for insulin receptor enables the preparation of novel immunogenic conjugates and antibodies raised against such conjugates. Novel therapeutically useful forms of the insulin receptor and anti-receptor antibodies are described.
501666
Bell John Richard
Ramachandran Janakiraman
Ullrich Axel
Dennison Associates
Genentech Inc.
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