Insulin receptor activators for the treatment of metabolic...

Details Insulin receptor activators for the treatment of metabolic... Insulin receptor activators for the treatment of metabolic...

A - Human Necessities

61

P

A61P 3/10 (2006.01) A61K 31/17 (2006.01) A61K 31/18 (2006.01) A61K 31/185 (2006.01) A61K 31/19 (2006.01) A61K 31/195 (2006.01) A61K 31/655 (2006.01) A61P 5/50 (2006.01) C07C 309/51 (2006.01) C07C 311/47 (2006.01)

Patent

CA 2421622

The present invention comprises the use of insulin receptor activating compounds, optionally in conjunction with insulin, for the treatment of HIV protease inhibitor-induced metabolic disorders. Any insulin receptor activating compounds is suitable for the practice of the invention. In addition, preferred compounds are disclosed. Methods of treating a person suffering from HIV protease inhibitor-induced metabolic disorders such as lipodystrophy, hypertriglyceridemia, insulin resistance, hyperglycemia, diabetes and ketoacidosis are also provided.

La présente invention concerne l'utilisation de composés activateurs du récepteur de l'insuline, éventuellement associés à l'insuline, pour le traitement de troubles métaboliques induits par l'inhibiteur de la VIH protéase. N'importe quel composé activateur du récepteur de l'insuline peut être mis en oeuvre pour la réalisation du principe de l'invention. On décrit des composés préférés, ainsi que des méthodes de traitement d'une personne atteinte de troubles métaboliques induits par l'inhibiteur de la VIH protéase, tels que la lipodystrophie, l'hypertriglycéridémie, la résistance à l'insuline, l'hyperglycémie, le diabète ou l'acidocétose.

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