Insulin secretion inducer, and accelerator for increasing...

Details Insulin secretion inducer, and accelerator for increasing... Insulin secretion inducer, and accelerator for increasing...

C - Chemistry, Metallurgy

07

K

C07K 14/575 (2006.01) A61K 38/10 (2006.01) A61P 3/10 (2006.01) A61P 5/50 (2006.01) C07K 7/08 (2006.01) C07K 14/605 (2006.01) C12N 15/16 (2006.01)

Patent

CA 2694222

Disclosed are: an insulin secretion inducer; an insulin secretion-inducing composition; a process for the production of the composition; an accelerator for increasing the number of pancreatic .beta.-cells; a composition for increasing the number of pancreatic .beta.-cells; a process for the production of the composition; and a viral vector for gene therapy. The insulin secretion inducer or the accelerator for increasing the number of pancreatic .beta.-cells comprises a polypeptide having an amino acid sequence encoded by DNA that is known to encode a membrane protein Tm4sf20 (transmembrane 4 L six family member 20) or the like or a fragment of the polypeptide as an active ingredient.

L'invention concerne : un indicateur de sécrétion d'insuline ; une composition induisant une sécrétion d'insuline ; un procédé de fabrication de la composition ; un accélérateur de croissance des cellules ß pancréatiques ; une composition destinée à accélérer la croissance des cellules ß pancréatiques ; un procédé de fabrication de la composition ; et un vecteur viral pour une thérapie génique. L'inducteur de sécrétion d'insuline ou l'accélérateur de croissance des cellules ß pancréatiques comprend un polypeptide possédant une séquence d'acides aminés codée par un ADN qui est connu pour coder une protéine membranaire Tm4sf20 (élément de famille 20 de transmembrane 4 L six) ou similaire, ou un fragment du polypeptide, en tant qu'ingrédient actif.

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