C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 43/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2489145
A compound or its salt inhibiting the activity of a protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO:1, an extracellular domain of the above protein, an antibody, an antisense polynucleotide, etc. are usable as agents improving insulin resistance and preventives/remedies for diabetes, obesity, hyperlipemia, arteriosclerosis, hypertension, heart diseases and so on.
L'invention concerne un composé ou son sel qui inhibent l'activité d'une protéine comprenant une séquence d'acide aminé identique ou sensiblement identique à la séquence d'acide aminé représentée par SEQ ID NO:1, un domaine extracellulaire de ladite protéine, un anticorps, un polynucléotide antisens, etc. qui peuvent tous être utilisés comme agents renforçateurs de la résistance à l'insuline et comme agents prophylactiques/thérapeutiques pour le diabète l'obésité, l'hyperlipémie, l'artériosclérose, l'hypertension, les maladies cardiaques, etc.
Henta Tsutomu
Sasada Reiko
Tojo Hideaki
Fetherstonhaugh & Co.
Takeda Pharmaceutical Company Limited
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