A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/56 (2006.01) A61K 31/138 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) C12N 15/09 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2609102
As a factor involved in hypoxia stress induction that enhances vasculaliation, Int6 is now identified successfully which is capable of binding to an HIF2.alpha. binding factor. It is found that Int6 can inhibit the transcription of an HIF2.alpha. hypoxia stress-inducible gene through the interaction between Int6 and HIF2.alpha.. A substance capable of inhibiting the expression or function of Int6 can enhance a promoting effect on the transcription of an HIF2.alpha. hypoxia stress-inducible gene to promote the vasculaliation, and therefore is expected to show a therapeutic effect on various vascular diseases such as myocardial infarction.
En tant que facteur impliqué dans le déclenchement du stress d~hypoxie qui améliore la vascularisation, Int6 est maintenant identifiée avec succès comme étant capable de se lier à un facteur liant HIF2a. On a découvert que la Int6 peut inhiber la transcription d~un gène HIF2a inductible au stress d~hypoxie par l~intermédiaire de l~interaction entre Int6 et HIF2a. Une substance capable d~inhiber l~expression ou la fonction de Int6 peut améliorer un effet de promotion sur la transcription d~un gène inductible au stress d~hypoxie HIF2a pour promouvoir la vascularisation, et de ce fait on espère qu~elle montre un effet thérapeutique sur diverses maladies vasculaires telles que l~infarctus du myocarde.
Chen Li
Sakata Kazuhiko
Shibasaki Futoshi
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Caretis Co. Ltd.
Chen Li
Sakata Kazuhiko
Shibasaki Futoshi
LandOfFree
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