Integrated protein affinity capture centrifugation device

Details Integrated protein affinity capture centrifugation device Integrated protein affinity capture centrifugation device

C - Chemistry, Metallurgy

40

B

C40B 60/12 (2006.01) C07K 1/22 (2006.01) C40B 60/00 (2006.01) G01N 30/72 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/68 (2006.01) G01N 30/38 (2006.01)

Patent

CA 2470799

A method and apparatus are described for screening a proteome comprising an array of affinity elements, whereby a proteome is directed through the affinity array and those components that specifically bind to the affinity array are eleuted in a suitable eluent by means of centrifugation. Suitable eluents can include a proteome component, a chemical library component or an affinity element. This method and apparatus can be used for several purposes, including screening for bio-active compounds, determining physiological targets of known drugs, determining specificity of compound interactions with physiological targets, and for quantitative protein analyses.

L'invention concerne un procédé et un appareil de criblage d'un protéome, qui comprend un jeu ordonné d'échantillons d'éléments d'affinité à travers lequel un protéome est dirigé; et les constituants qui se lient spécifiquement audit jeu d'échantillons sont élués dans un éluant approprié, par centrifugation. Des éluants appropriés peuvent comprendre un constituant du protéome, un constituant de bibliothèque chimique ou élément d'affinité. Le procédé et l'appareil de l'invention peuvent être mis en oeuvre à diverses fins, notamment pour un criblage destiné à identifier des composés bioactifs, à déterminer des cibles physiologiques de médicaments connus, à déterminer la spécificité d'interactions de composés avec des cibles physiologiques, ou pour des analyses protéiques quantitatives.

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