Integrative recombinant adenoviruses, preparation thereof...

Details Integrative recombinant adenoviruses, preparation thereof... Integrative recombinant adenoviruses, preparation thereof...

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/775 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 15/11 (2006.01) C12N 15/861 (2006.01) C12N 15/864 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2184113

Recombinant adenoviruses comprising a cassette which can be integrated into the genome of infected cells, the preparation thereof, pharmaceutical compositions containing same, and uses of said adenoviruses, are disclosed. The cassette particularly contains at least one inverted terminal repeat (ITR) of an AAV and a heterologous DNA sequence.

La présente invention concerne des adénovirus re- combinants comportant une cassette capable de s'intégrer dans le génome des cellules infectées, leur préparation, les compositions pharmaceutiques les contenant, et leur util- isation. En particulier, la cassette contient au moins une séquence terminale inverse-répétée (ITR) d'AAV et une séquence d'ADN hétérologue.

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